It's almost impossible to identify performance bottlenecks before a program is working completely. Programmers are very bad at guessing which four percent of the code accounts for 50 percent of the execution time, and so programmers who optimize as they go will, on average, spend 96 percent of their time optimizing code that doesn't need to be optimized. That leaves little time to optimize the four percent that really counts.

Steve McConnell, Code Complete, Second Edition